Melanotan 1 is a synthetic 13-amino-acid peptide engineered as a more stable and potent analog of the endogenous hormone α-MSH. It is also known in the literature as afamelanotide, NDP-α-MSH, or [Nle⁴, D-Phe⁷]-α-MSH.
In research settings, Melanotan 1 is studied primarily for its activity as a melanocortin receptor agonist, with preferential affinity for the MC1 receptor. Activation of MC1R on melanocytes is linked to stimulation of eumelanin production pathways.
Research applications typically focus on:
Melanocortin receptor binding and signaling assays
Melanogenesis and pigment cell biology models
Photoprotection-related cellular responses
Comparative studies versus cyclic analogs such as Melanotan 2
It is generally supplied as a lyophilized powder for laboratory reconstitution and is strictly intended for in-vitro and controlled research use.
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