Selank is a synthetic 7-amino-acid peptide developed as an analog of tuftsin (Thr-Lys-Pro-Arg), a naturally occurring fragment of immunoglobulin G. The addition of the C-terminal Pro-Gly-Pro sequence increases resistance to enzymatic degradation while retaining and expanding the parent peptide’s activity profile.
In laboratory research, Selank has been examined for its interactions with multiple systems:
Modulation of GABA-A receptor activity and inhibitory neurotransmission
Inhibition of enkephalin-degrading enzymes, potentially influencing endogenous opioid peptide levels
Effects on BDNF expression and neurotrophic signaling
Influence on cytokine balance and T-helper cell activity in immune models
Anxiolytic-like and cognitive-related behavioral outcomes in preclinical systems
Molecular details commonly listed for research material:
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular formula: C₃₃H₅₇N₁₁O₉
Molecular weight: ≈ 751.9 Da
CAS: 129954-34-3
It is typically supplied as a white to off-white lyophilized powder for reconstitution in laboratory solvents. All material is strictly for in-vitro and controlled laboratory research.
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